NeuroEpigenetics Laboratory

The knowledge of epigenetics mechanisms is crucial not only to better understand normal brain development, plasticity and function, but also to dissect chromatin pathways malfunctioning in diseases, thus providing new and powerful tools of intervention through the identification of possible disease modifiers, druggable molecules to be challenged or protected during the early phases of the disease progression. Our laboratory aims to investigate the epigenetic basis of complex brain functions and how alterations in chromatin remodeling complexes,
histone modifications patterns and non-coding RNAs might contribute to neurodegenerative and neurodevelopmental disorders, specifically HUNTINGTON’S DISEASE and AUTISM.